Malignant pleural mesothelioma (MPM) grows aggressively within the thoracic cavity and has a very low cure rate, thus highlighting the need for identification of new therapeutic targets. Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor–like receptor/receptor activity–modifying protein 2 (CLR/RAMP2) and calcitonin receptor–like receptor/receptor activity–modifying protein 3 (CLR/RAMP3).