Published in
Elsevier, Diabetes Research and Clinical Practice, 1(102), p. e1-e4
DOI: 10.1016/j.diabres.2013.08.005
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Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: Implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo
Journal article published in 2013 by
Daisuke Yabe 
,
Mariyo Rokutan,
Yoshiyuki Miura,
Izumi Komoto,
Ryota Usui,
Hitoshi Kuwata,
Koin Watanabe,
Takanori Hyo,
Takeshi Kurose,
Terumi Nagamatsu,
Shinobu Shimizu,
Jun Kawai,
Masayuki Imamura,
Yutaka Seino
,
Mariyo Rokutan,
Yoshiyuki Miura,
Izumi Komoto,
Ryota Usui,
Hitoshi Kuwata,
Koin Watanabe,
Takanori Hyo,
Takeshi Kurose,
Terumi Nagamatsu,
Shinobu Shimizu,
Jun Kawai,
Masayuki Imamura,
Yutaka Seino
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Abstract
We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.