Published in

Wiley-VCH Verlag, ChemInform, 17(38), 2007

DOI: 10.1002/chin.200717145

Elsevier, European Journal of Medicinal Chemistry, 12(41), p. 1464-1469

DOI: 10.1016/j.ejmech.2006.06.016

Links

Tools

Export citation

Search in Google Scholar

Synthesis and Biological Evaluation of New 4H-Pyrano[2,3-b]quinoline Derivatives that Block Acetylcholinesterase and Cell Calcium Signals, and Cause Neuroprotection Against Calcium Overload and Free Radicals

Journal article published in 2006 by José Marco-Contelles, Rafael León, Manuela G. López ORCID, Antonio G. García, Mercedes Villarroya
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The synthesis and biological evaluation of ethyl 5-amino-4-(3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylates (9-11) is described. We have found that these compounds inhibit AChE with a mild potency, mitigates the [Ca(2+)](c) triggered by high K(+), and cause neuroprotection against Ca(2+) overloading and free radical-induced neuronal death.