A micropattern-induced transition in the mechanism of vortex motion and vortex mobility is observed in high-Tc thin films. The competition between the anomalous Hall effect and the guidance of vortices by rows of microholes (antidots) lead to a sudden change in the direction of vortex motion that is accompanied by a change in the critical current density and microwave losses. The latter effect demonstrates the difference in vortex mobility in different phases of vortex motion in between and within the rows of antidots.