New loci associated with kidney function and chronic kidney disease

Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Anna,; Carsten, A.; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L.; Parsa, Afshin; Gao, Xiaoyi; K{̈o}ttgen, Anna; Yang, Qiong; Smith, Albert V.; O'Connell, Jeffrey R.; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Jeffrey, R.; Johnson, Andrew D.; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J.; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C.; Probst-Hensch, Nicole M.; Guillaume,; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore J.; Harris, Tamara B.; Rampersaud, Evadnie; Mitchell, Braxton D.; Arking, Dan E.; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Anke,; Giallauria, Francesco; Metter, Jeffrey; de Boer, Ian H.; B{̈o}ger, Carsten A.; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M.; Zillikens, M. Carola; Oostra, Ben A.; Feitosa, Mary; Province, Michael; de Andrade, Mariza; Turner, Stephen T.; Schillert, Arne; Ziegler, Andreas; Carola Zillikens, M.; Wild, Philipp S.; Schnabel, Renate B.; Wilde, Sandra; Munzel, Thomas F.; Leak, Tennille S.; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H.-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Erich Wichmann, H.; Hu, Frank B.; Johansson, Asa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H.; Wright, Alan F.; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S.; Felix, Janine F.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandst&amp;auml;tter, Anita; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; M&amp;auml;gi, Reedik; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K.; Henry,; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N.; Uwe,; Ridker, Paul M.; Kardia, Sharon L. R.; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C.; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R.; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G.; van Duijn, Cornelia M.; Borecki, Ingrid; Kr&amp;auml;mer, Bernhard K.; Krämer, Bernhard K.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Witteman, Jacqueline C.; Pramstaller, Peter P.; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I.; Kao, W. H.; Heid, Iris M.; Fox, Caroline S.; Others,

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Albert V. Smith
Köttgen et al., 2010

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@article{Köttgen2010,
  abstract = {Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea &lt; 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P &lt; 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.},
  author = {Köttgen, Anna and Pattaro, Cristian and Böger, Carsten A. and Anna,  and Carsten, A. and Fuchsberger, Christian and Olden, Matthias and Glazer, Nicole L. and Parsa, Afshin and Gao, Xiaoyi and K{̈o}ttgen, Anna and Yang, Qiong and Smith, Albert V. and O'Connell, Jeffrey R. and Li, Man and Schmidt, Helena and Tanaka, Toshiko and Isaacs, Aaron and Ketkar, Shamika and Hwang, Shih-Jen and Jeffrey, R. and Johnson, Andrew D. and Dehghan, Abbas and Teumer, Alexander and Paré, Guillaume and Atkinson, Elizabeth J. and Zeller, Tanja and Lohman, Kurt and Cornelis, Marilyn C. and Probst-Hensch, Nicole M. and Guillaume,  and Kronenberg, Florian and Tönjes, Anke and Hayward, Caroline and Aspelund, Thor and Eiriksdottir, Gudny and Launer, Lenore J. and Harris, Tamara B. and Rampersaud, Evadnie and Mitchell, Braxton D. and Arking, Dan E. and Boerwinkle, Eric and Struchalin, Maksim and Cavalieri, Margherita and Singleton, Andrew and Anke,  and Giallauria, Francesco and Metter, Jeffrey and de Boer, Ian H. and B{̈o}ger, Carsten A. and Haritunians, Talin and Lumley, Thomas and Siscovick, David and Psaty, Bruce M. and Zillikens, M. Carola and Oostra, Ben A. and Feitosa, Mary and Province, Michael and de Andrade, Mariza and Turner, Stephen T. and Schillert, Arne and Ziegler, Andreas and Carola Zillikens, M. and Wild, Philipp S. and Schnabel, Renate B. and Wilde, Sandra and Munzel, Thomas F. and Leak, Tennille S. and Illig, Thomas and Klopp, Norman and Meisinger, Christa and Wichmann, H.-Erich and Koenig, Wolfgang and Zgaga, Lina and Zemunik, Tatijana and Kolcic, Ivana and Minelli, Cosetta and Erich Wichmann, H. and Hu, Frank B. and Johansson, Asa and Igl, Wilmar and Zaboli, Ghazal and Wild, Sarah H. and Wright, Alan F. and Campbell, Harry and Ellinghaus, David and Schreiber, Stefan and Aulchenko, Yurii S. and Felix, Janine F. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Hofman, Albert and Imboden, Medea and Nitsch, Dorothea and Brandst&amp;auml;tter, Anita and Brandstätter, Anita and Kollerits, Barbara and Kedenko, Lyudmyla and M&amp;auml;gi, Reedik and Mägi, Reedik and Stumvoll, Michael and Kovacs, Peter and Boban, Mladen and Campbell, Susan and Endlich, Karlhans and Völzke, Henry and Kroemer, Heyo K. and Henry,  and Nauck, Matthias and Völker, Uwe and Polasek, Ozren and Vitart, Veronique and Badola, Sunita and Parker, Alexander N. and Uwe,  and Ridker, Paul M. and Kardia, Sharon L. R. and Blankenberg, Stefan and Liu, Yongmei and Curhan, Gary C. and Franke, Andre and Rochat, Thierry and Paulweber, Bernhard and Prokopenko, Inga and Wang, Wei and Gudnason, Vilmundur and Shuldiner, Alan R. and Coresh, Josef and Schmidt, Reinhold and Ferrucci, Luigi and Shlipak, Michael G. and van Duijn, Cornelia M. and Borecki, Ingrid and Kr&amp;auml;mer, Bernhard K. and Krämer, Bernhard K. and Rudan, Igor and Gyllensten, Ulf and Wilson, James F. and Witteman, Jacqueline C. and Pramstaller, Peter P. and Rettig, Rainer and Hastie, Nick and Chasman, Daniel I. and Kao, W. H. and Heid, Iris M. and Fox, Caroline S. and Others, },
  doi = {10.1038/ng.568},
  month = {jan},
  title = {New loci associated with kidney function and chronic kidney disease},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/20383146},
  year = {2010}
}

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New loci associated with kidney function and chronic kidney disease

Journal article published in 2010 by Anna Köttgen, Cristian Pattaro, Carsten A. Böger, Anna, A. Carsten, Christian Fuchsberger, Matthias Olden, Nicole L. Glazer, Afshin Parsa, Xiaoyi Gao, Anna K{̈o}ttgen, Qiong Yang, Albert V. Smith

, Jeffrey R. O'Connell, Man Li and other authors. Anna Köttgen, Cristian Pattaro, Carsten A. Böger, Anna, A. Carsten, Christian Fuchsberger, Matthias Olden, Nicole L. Glazer, Afshin Parsa, Xiaoyi Gao, Anna K{̈o}ttgen, Qiong Yang, Albert V. Smith

, Jeffrey R. O'Connell, Man Li, Helena Schmidt, Toshiko Tanaka, Aaron Isaacs, Shamika Ketkar, Shih-Jen Hwang, R. Jeffrey, Andrew D. Johnson, Abbas Dehghan

, Alexander Teumer, Guillaume Paré, Elizabeth J. Atkinson, Tanja Zeller, Kurt Lohman, Marilyn C. Cornelis, Nicole M. Probst-Hensch, Guillaume, Florian Kronenberg, Anke Tönjes, Caroline Hayward, Thor Aspelund, Gudny Eiriksdottir, Lenore J. Launer, Tamara B. Harris, Evadnie Rampersaud, Braxton D. Mitchell, Dan E. Arking, Eric Boerwinkle, Maksim Struchalin, Margherita Cavalieri, Andrew Singleton, Anke, Francesco Giallauria, Jeffrey Metter, Ian H. de Boer, Carsten A. B{̈o}ger, Talin Haritunians, Thomas Lumley, David Siscovick, Bruce M. Psaty, M. Carola Zillikens, Ben A. Oostra, Mary Feitosa, Michael Province, Mariza de Andrade, Stephen T. Turner, Arne Schillert, Andreas Ziegler, M. Carola Zillikens, Philipp S. Wild, Renate B. Schnabel, Sandra Wilde, Thomas F. Munzel, Tennille S. Leak, Thomas Illig, Norman Klopp, Christa Meisinger

, H.-Erich Wichmann, Wolfgang Koenig, Lina Zgaga, Tatijana Zemunik, Ivana Kolcic, Cosetta Minelli, H. Erich Wichmann, Frank B. Hu, Asa Johansson, Wilmar Igl, Ghazal Zaboli, Sarah H. Wild, Alan F. Wright, Harry Campbell, David Ellinghaus, Stefan Schreiber, Yurii S. Aulchenko, Janine F. Felix, Fernando Rivadeneira, Andre G. Uitterlinden, Albert Hofman, Medea Imboden, Dorothea Nitsch, Anita Brandst&auml;tter, Anita Brandstätter, Barbara Kollerits

, Lyudmyla Kedenko, Reedik M&auml;gi, Reedik Mägi

, Michael Stumvoll, Peter Kovacs, Mladen Boban, Susan Campbell, Karlhans Endlich, Henry Völzke, Heyo K. Kroemer, Henry, Matthias Nauck, Uwe Völker, Ozren Polasek, Veronique Vitart, Sunita Badola, Alexander N. Parker, Uwe, Paul M. Ridker, Sharon L. R. Kardia, Stefan Blankenberg, Yongmei Liu, Gary C. Curhan, Andre Franke, Thierry Rochat, Bernhard Paulweber, Inga Prokopenko

, Wei Wang

, Vilmundur Gudnason, Alan R. Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, Michael G. Shlipak, Cornelia M. van Duijn, Ingrid Borecki, Bernhard K. Kr&auml;mer, Bernhard K. Krämer, Igor Rudan, Ulf Gyllensten, James F. Wilson, Jacqueline C. Witteman, Peter P. Pramstaller

, Rainer Rettig, Nick Hastie, Daniel I. Chasman, W. H. Kao, Iris M. Heid, Caroline S. Fox, Others

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Abstract

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

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New loci associated with kidney function and chronic kidney disease

Abstract