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Novel Hydroxamic Acids Having Histone Deacetylase Inhibiting Activity and Anti-Cancer Composition Comprising the Same As An Active Ingredient
Journal article published in 2012 by
Nguyen Hai Nam,
Van Thi My Hue,
Dao Thi Kim Oanh,
Sang-Bae Han,
Truong Thanh Tung 
,
Young Soo Kim,
Jin Tae Hong,
Han Sang Bae ; Kim Young Soo ; Hong Jin Tae ; Nguyen Hai Nam ; Van Thi My Hue ; Dao Thi Kim Oanh
,
Young Soo Kim,
Jin Tae Hong,
Han Sang Bae ; Kim Young Soo ; Hong Jin Tae ; Nguyen Hai Nam ; Van Thi My Hue ; Dao Thi Kim Oanh
Abstract
The present invention relates to a pharmaceutical composition for anticancer including novel hydroxamic acid with histone deacetylase inhibiting activity as an active ingredient. Hydroxamic acid compound of the present invention has inhibitory activity of histone deacetylase (HDAC) and shows cytotoxicity to a variety of cancer cells, being useful in strong anti-cancer drug.