In this study, a novel multifunctional hybrid polymer-based luminescent material especially formulated for photolithography was developed for the fabrication and testing as miniaturized chemosensor. This nanocomposite is formulated with either luminescent CdSe (for the visible) or PbS (for the near-IR) colloidal QDs embedded in a polyisoprene-based photoresist (PIP). We checked the 10 sensing capability of the nanocomposite by exposing 1 cm 2 CdSe nanocomposite patterns to vapours of some analyte solutions like 2-mercaptoethanol (MET) and ethylenediamine (EDA). The transduction mechanism of the sensor is based on changes of the QD photoluminescence (PL) when molecules are adsorbed on the QD surface. Since the polymer used suffers from swelling during the development step of the sensor fabrication, the diffusion of the analytes through the matrix is rather high. As a result, the sensor response to the analyte-QD interactions is considerably short and sensitive. We observed shorter sensor response times 15 to MET than EDA. Moreover, we found a limit of detection of MET and EDA of 0.1 pg and 10 ng respectively. The linear detection range for MET and EDA was determined to be over an analyte concentration of 6 and 5 orders of magnitude respectively. We also tested the PbS-based nanocomposite response to MET and EDA and found very different response. Whereas EDA quenches the PbS PL, exposure to MET molecules resulted in a 6.5-fold enhancement of the PL. The mechanisms of the observed effects are discussed in detail. 20