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Facultad de Humanidades y Ciencias de la Educación, Synthesis: Journal of Synthetic Organic Chemistry, 10(47), p. 1413-1422

DOI: 10.1055/s-0034-1380405

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An Efficient Route to Novel Uracil-Based Drug-Like Molecules

Journal article published in 2015 by Denis A. Babkov, Katherine L. Seley-Radtke, Alexander O. Chizhov, Anastasia L. Khandazhinskaya, Angela Corona ORCID, Francesca Esposito, Enzo Tramontano ORCID, Mikhail S. Novikov
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In order to identify new antiretroviral agents, a series of novel uracil derivatives have been synthesized. Optimized conditions for coupling of Weinreb amides with aromatic Grignard reagents allow the convenient preparation of key benzophenone intermediates in high yields and purities. The use of a modified silyl Hilbert–Johnson reaction affords the target compounds under mild conditions.