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Cell Press, Chemistry and Biology, 12(19), p. 1499-1500, 2012

DOI: 10.1016/j.chembiol.2012.12.003

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A new drug for an old bug

Journal article published in 2012 by Peter J. Myler ORCID, Robin Stacy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

There is an urgent need to develop new drugs for the treatment of tuberculosis, particularly against latent/persistent forms of the causative agent, Mycobacterium tuberculosis. In this issue of Chemistry & Biology, Krieger and colleagues use a structure-guided approach to develop novel inhibitors of malate synthase, a target in the glyoxylate shunt that is critical for pathogen survival in chronic infection.