Published in
American Society for Microbiology, Journal of Clinical Microbiology, 1(51), p. 356-359, 2013
DOI: 10.1128/jcm.02247-12
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- American Society for Microbiology | PDF
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Neonatal Herpes Encephalitis Caused by a Virologically Confirmed Acyclovir-Resistant Herpes Simplex Virus 1 Strain
Journal article published in 2012 by
Satsuki Kakiuchi,
Shigeaki Nonoyama,
Hajime Wakamatsu,
Kazuhiro Kogawa,
Lixin Wang,
Hitomi Kinoshita-Yamaguchi,
Mutsuyo Takayama-Ito 
,
Chang-Kweng Lim,
Naoki Inoue,
Masashi Mizuguchi,
Takashi Igarashi,
Masayuki Saijo
,
Chang-Kweng Lim,
Naoki Inoue,
Masashi Mizuguchi,
Takashi Igarashi,
Masayuki Saijo
This paper is made freely available by the publisher.
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Abstract
ABSTRACT A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.