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Royal Society of Chemistry, RSC Advances, 36(5), p. 28219-28227

DOI: 10.1039/c5ra03871e

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In vitro and in vivo studies of temozolomide loading in zeolite structures as drug delivery systems for glioblastoma

Journal article published in 2015 by Olga Martinho, Natália Vilaça, Paulo J. G. Castro, Ricardo Amorim, António M. Fonseca ORCID, Fátima Baltazar, Rui M. Reis, Isabel C. Neves
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Y and MOR zeolites were used as a host for the temozolomide (TMZ). Y presented toxicity to glioblastoma cancer cells in contrast to MOR. Higher potentiation of TMZ was obtained with MOR in comparison to free TMZ bothin vitroandin vivo.