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Royal Society of Chemistry, RSC Advances, 21(5), p. 15756-15762, 2015

DOI: 10.1039/c4ra15038d

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Effect of overexpression of endogenous and exogenous Streptomyces antibiotic regulatory proteins on tacrolimus (FK506) production in Streptomyces sp. KCCM11116P

Journal article published in 2015 by Chao Chen, Xinqing Zhao, Liangyu Chen, Yingyu Jin, Zongbao K. Zhao ORCID, Joo-Won Suh
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Overexpression of SARPs enhanced FK506 production in Streptomyces sp. KCCM1116P. The endogenous SARPs improved production titer, whereas the exogenous SARP enhanced productivity at the early fermentation stage.