Rosenberger, Albert Bickeboller, Heike McCormack, Valerie Brenner, Darren R Duell, Eric J Tjonneland, Anne Friis, Soren Muscat, Joshua E Yang, Ping Wichmann, H-Erich Heinrich, Joachim Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Zaridze, David Rudnai, Peter Fabianova, Eleonora Janout, Vladimir Bencko, Vladimir Brennan, Paul Mates, Dana Schwartz, Ann G Cote, Michele L Zhang, Zuo-Feng Morgenstern, Hal Oh, Sam S Field, John K Raji, Olaide McLaughlin, John R Wiencke, John LeMarchand, Loic Neri, Monica Bonassi, Stefano Andrew, Angeline S Lan, Qing Hu, Wei Orlow, Irene Park, Bernard J Boffetta, Paolo Hung, Rayjean J eng 1U19CA148127-01/CA/NCI NIH HHS/ CA-113710/CA/NCI NIH HHS/ CA77118/CA/NCI NIH HHS/ CA80127/CA/NCI NIH HHS/ ES06717/ES/NIEHS NIH HHS/ N01-PC35145/PC/NCI NIH HHS/ P30 CA022453/CA/NCI NIH HHS/ P30CA22453/CA/NCI NIH HHS/ R01 CA060691/CA/NCI NIH HHS/ R01 CA087895/CA/NCI NIH HHS/ R01 ES006717/ES/NIEHS NIH HHS/ R01CA060691/CA/NCI NIH HHS/ R01CA87895/CA/NCI NIH HHS/ R25 CA113710/CA/NCI NIH HHS/ U19 CA148127/CA/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2011/12/27 06:00 Carcinogenesis. 2012 Mar;33(3):587-97. doi: 10.1093/carcin/bgr307. Epub 2011 Dec 22. ; International audience ; Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I(2) = 73%, P