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Wnt signaling and Dupuytren's disease.
Journal article published in 2011 by
Gh H. Dolmans,
Pm M. Werker,
Hc C. Hennies,
Dominic Furniss,
Ea A. Festen,
Lude Franke 
,
Kerstin Becker,
Pieter van der Vlies,
Bh H. Wolffenbuttel,
Sigrid Tinschert,
Mr R. Toliat,
Michael Nothnagel,
Andre Franke,
Norman B. Klopp,
H. Erich Wichmann
and other authors.
,
Kerstin Becker,
Pieter van der Vlies,
Bh H. Wolffenbuttel,
Sigrid Tinschert,
Mr R. Toliat,
Michael Nothnagel,
Andre Franke,
Norman B. Klopp,
H. Erich Wichmann
and other authors.
Abstract
BACKGROUND: Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis. METHODS: We conducted a genomewide association study of 960 Dutch persons with Dupuytren's disease and 3117 controls (the discovery set) to test for association between the disease and genetic markers. We tested the 35 single-nucleotide polymorphisms (SNPs) most strongly associated with Dupuytren's disease (P