A two-stage meta-analysis identifies several new loci for Parkinson's disease.

van Dijk, Kd; van Hilten, Jj; de Silva, R.; van de Warrenburg, B.; Wtccc2,; Nalls,; Plagnol, V. M.; Sharma, M.; Sheerin, Um M.; Schulte, C.; Sveinbjornsdottir, S.; Lorenz, D.; Saad, M.; Simon-Sanchez, J.; Una Marie Sheerin, C.; Lesage, S.; Lichtner, P.; Pollak, P.; Limousin, P.; Lopez, G.; McNeill, A.; Moorby, C.; de Bie, Rma; Moore, M.; Morris, H. A.; Morrison, Ke E.; Mudanohwo, E.; O'Sullivan, Ss S.; Pearson, J.; Pearson, R.; Perlmutter, Js; Petursson, H.; Pirinen, M.; Post, B.; Potter, S. C.; Ravina, B.; Revesz, T.; Riess, O.; Rivadeneira, F.; Rizzu, P.; Ryten, M.; Sawcer, S. J.; Schapira, A.; Scheffer, H.; Shaw, K.; Shoulson, I.; Sidransky, E.; Polnak, P.; Smith, C.; Spencer, Cca C.; Stefansson, H.; Steinberg, S.; Huttenlocher, J.; Stockton,; Illig, T.; Strange, A.; Jonsson, Pv; Su, Z.; Langford, C.; Talbot, K.; Lees, A. J.; Tanner, Cm M.; Tashakkori-Ghanbaria, A.; Silva, R. de; Tison, F.; Trabzuni, D.; Traynor, Bj J.; Uitterlinden, Ag G.; Vandrovcova, J.; Velseboer, D.; Vidailhet, M.; Vukcevic, D.; Walker, R.; Weale, Me E.; Wickremaratchi, M.; Williams, N.; Warrenburg, B. P. C. van de; Williams-Gray, Ch H.; Winder-Rhodes, S.; Stefansson, K.; Martinez, M.; Singleton,; Wood, Nw W.; Lichter, P.; Bras, Jm M.; Hernandez, Dg; Band, G.; Bellinguez, C.; Bie, R. M. de; Berg, D.; Bonin, M.; Brockmann, K.; Brooks, J.; Burn, Dj J.; Counsell, J.; Charlesworth, G.; Chen, Hl; Amouyel, P.; Chinnery, Pf F.; Chong, S.; Dijk, K. D. van; Arepalli, S.; Clarke, Ce E.; Cookson, Mr R.; Barker, Ra A.; Cooper, Jm M.; Corvol, Jc C.; Damier, P.; Dartigues, Jf F.; Deloukas, P.; Ben-Shlomo, Y.; Deuschl, G.; Dexter, Dt T.; Berendse, Hw W.; Hilten, J. J. van; Durif, F.; Durr, A.; Counsell, C.; Bloem, B. R.; Edkins, S.; Evans,; Foltynie, T.; Bochdanovits, Z.; Freeman, C.; Bhatia, K. P.; Gao, Jj; Gardner, M.; Biffi, A.; Barrett, J.; Gibbs,; Goate, A.; Gray, E.; Guerreiro, R.; Gustafsson, O.; Harris, C.; Hellenthal, G.; Hofman, A.; Hollenbeck, A.; Holton, J. L.; Hu, M.; Huang, Xm; Dillman, Allissa; Hudson, G.; Hunt, Se E.; Huber, H.; Br,; Donnelly, P.; Hardy, J.; Heutink, P.; Brice, A.; Gasser, T.; (Ipdgc), International Parkinson's Disease Genomics Consortium; 2 (Wtccc2), Wellcome Trust Case Control Consortium

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Public Library of Science, PLoS Genetics, 6(7), p. e1002142, 2011

DOI: 10.1371/journal.pgen.1002142

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A two-stage meta-analysis identifies several new loci for Parkinson's disease.

Journal article published in 2011 by Kd van Dijk, Jj van Hilten, R. de Silva, B. van de Warrenburg, Wtccc2, Nalls, V. M. Plagnol, M. Sharma, Um M. Sheerin, C. Schulte, S. Sveinbjornsdottir, D. Lorenz, M. Saad, J. Simon-Sanchez, C. Una Marie Sheerin and other authors.

This paper is made freely available by the publisher.

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Abstract

A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p

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A two-stage meta-analysis identifies several new loci for Parkinson's disease.

Abstract