Abstract Lightning initiation (LI) events over Florida and Oklahoma are examined and statistically compared to understand the behavior of observed radar and infrared satellite interest fields (IFs) in the 75-min time frame surrounding LI. Lightning initiation is defined as the time of the first lightning, of any kind, generated in a cumulonimbus cloud. Geostationary Operational Environmental Satellite (GOES) infrared IFs, contoured frequency by altitude diagrams (CFADs) of radar reflectivity, and model sounding data, analyzed in concert, show the mean characteristics over time for 36 and 23 LI events over Florida and Oklahoma, respectively. CFADs indicate that radar echoes formed 60 min before Florida LI, yet Oklahoma storms exhibited a ~30-min delayed development. Large ice volumes in Florida developed from the freezing of lofted liquid hydrometeors formed by long-lived (~45 min) warm rain processes, which are mostly absent in Oklahoma. However, ice volumes developed abruptly in Oklahoma storms despite missing a significant warm rain component. GOES fields were significantly different before 30 min prior to LI between the two locations. Compared to Florida storms, lower precipitable water (PW), higher convective available potential energy, and higher 3.9-μm reflectance in Oklahoma, suggest stronger and drier updrafts producing a greater abundance of small ice particles. Somewhat larger 15-min 10.7-μm cooling rates in Oklahoma confirm stronger updrafts, while clouds in the 60–30-min pre-LI period show more IF variability (e.g., in the 6.5–10.7-μm difference). Florida storms (high PW, slower growth) offer more lead time for LI predictability, compared to Oklahoma storms (low PW, explosive growth), with defined anvils being obvious at the time of LI.