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Wiley, Small, 16(8), p. 2477-2482, 2012

DOI: 10.1002/smll.201200110

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Self-Assembled Magnetic Bead Biosensor for Measuring Bacterial Growth and Antimicrobial Susceptibility Testing

Journal article published in 2012 by Paivo Kinnunen ORCID, Brandon H. McNaughton, Theodore Albertson, Irene Sinn, Sima Mofakham, Remy Elbez, Duane W. Newton, Alan Hunt, Raoul Kopelman
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This paper is available in a repository.

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Abstract

Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.