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Anticarbohydrate Antibodies, p. 385-402

DOI: 10.1007/978-3-7091-0870-3_16

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The Interaction of Saccharides with Antibodies. A 3D View by Using NMR

Journal article published in 2011 by Filipa Marcelo, F. Javier Cañada, Jesús Jiménez-Barbero ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The study of molecular recognition phenomena has occupied the minds and the hearts of many scientists during the last decades (Rebek 2009). The understanding of these events is of paramount importance to achieve a better knowledge of the living systems. Nowadays, it is clear that carbohydrates play a key role in a variety of biological processes (Varki et al. 1999). They appear in all cells, in different forms, and they are implicated in many cellular processes, including cell-cell recognition, cellular transport, and adhesion. Carbohydrate-mediated interactions are also concerned in diverse disease mechanisms, especially in the immune system (Avci and Kasper 2010; Engering et al. 2002). Bacteria and viruses contain unique carbohydrates on their surfaces, and these saccharide molecules are often those first recognized by the human immune system. Therefore, carbohydrates would, in theory, be good vaccine candidates educating the immune system to create antibodies (Johnson and Pinto 2008).