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Elsevier, The Lancet Oncology, 2(17), p. 184-192, 2016

DOI: 10.1016/s1470-2045(15)00482-9

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Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial

Journal article published in 2016 by Andrew J. Hayes, Lauren Maynard, Gillian Coombes, Julia Newton-Bishop ORCID, Michael Timmons, Martin Cook, Jeffrey Theaker, Judith M. Bliss, J. Meirion Thomas, J. Meirion Thomas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The necessary margin of excision for cutaneous melanomas greater than 2 mm in thickness is controversial. At a median follow-up of 5 years, findings from our previously published randomised trial of narrow (1 cm) versus wide (3 cm) excision margins in patients with thick cutaneous melanomas showed that narrow margins were associated with an increased frequency of locoregional relapse, but no significant difference in overall survival was apparent. We now report a long-term survival analysis of that trial.