In this work, we introduce a novel approach for the fabrication of temperature sensors. The devices are based on the integration of an Organic Charge Modulated Field Effect Transistor (OCMFET) with a pyroelectric polymeric element. Thanks to the optimization of the gate dielectric structure the fabricated sensors can be operated at very low voltages, and moreover, are fabricated on highly flexible plastic substrates. The results demonstrate that the sensors are able to detect in a very reproducible way, temperature variations from 20 °C up to 50 °C. This architecture represents a simple and innovative solution for the realization of conformable sensing systems for applications in tactile sensing as well as in wearable electronics.