Published in
Elsevier, Tetrahedron Letters, 5(42), p. 863-865
DOI: 10.1016/s0040-4039(00)02136-5
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A mild and efficient method for the regioselective iodination of pyrazoles
Journal article published in 2001 by
M. I. Rodrguez Franco 
,
Isabel Dorronsoro,
Ana I. Hernández Higueras,
Gema Antequera
,
Isabel Dorronsoro,
Ana I. Hernández Higueras,
Gema Antequera
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Abstract
The iodination of N-H or N-benzylpyrazoles using elemental iodine in the presence of CAN as the in situ oxidant is a mild and efficient method to prepare 4-iodopyrazoles containing even electron-withdrawing substituents. The reaction is regioselective since the iodine atom preferred pyrazole instead of the benzyl group, and the 4-pyrazolic position instead of other possible positions in the heterocycle.