We demonstrate fabrication of highly functional biomicrochips by hybrid femtosecond laser processing. In this process, 3D microfluidic structures are first formed inside photosensitive glass by femtosecond laser direct writing followed by thermal treatment and successive chemical wet etching. Then, functional microcomponents are integrated inside the fabricated microfluidic structures by two-photon photopolyerization. We term the fabricated microchips ship-in-a-bottle biomicrochips