Published in

EMBO Press, EMBO Reports, 9(15), p. 1000-1000, 2014

DOI: 10.15252/embr.201439354

EMBO Press, EMBO Reports, 6(13), p. 554-560, 2012

DOI: 10.1038/embor.2012.53

Links

Tools

Export citation

Search in Google Scholar

AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis

Journal article published in 2012 by Haitao Ji, Zhiyong Ding, David Hawke, Dongming Xing, Bing-Hua Jiang ORCID, Gordon B. Mills, Zhimin Lu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleophosmin from the MDM2 complex. This leads to the promotion of MDM2-p53 interaction and subsequent p53 degradation, thereby providing an antiapoptotic effect. Conversely, depletion of or deficiency in Niban expression promotes stabilization of p53 with increased cell apoptosis. Our findings illustrate a pivotal role for AKT-mediated phosphorylation of Niban in protecting cells from genotoxic stress-induced cell apoptosis.