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Wiley, European Journal of Immunology, 6(43), p. 1445-1448, 2013

DOI: 10.1002/eji.201343644



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With(out) a little help from my friends: An IL-12/CD40L-mediated feed-forward loop between CD8+T cells and DCs

Journal article published in 2013 by Martijn A. Nolte ORCID, Rene A. W. van Lier
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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CD40-CD40L interactions are important for both antigen-dependent B-cell differentiation and effector and memory T-cell formation. The prevailing view is that CD40L is expressed on activated CD4(+) T cells, which enables them to provide help to high-affinity B cells in germinal centers and to license DCs for efficient induction of CD8(+) T-cell responses. Interestingly, CD8(+) T cells themselves can also express CD40L and, in this issue of the European Journal of Immunology, Thiel and colleagues [Eur. J. Immunol. 2013. 43: XXXX-XXXX] show that CD40L expression on these cells can be part of a self-sustaining feed-forward loop, in which expression of CD40L is induced by IL-12 and TCR signaling. This provides a paradigm shift in our thinking about the requirements of effector CD8(+) T-cell development and the role herein of CD4(+) T cells to provide help in this process. This article is protected by copyright. All rights reserved.