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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(57), p. 2874-2877, 2013

DOI: 10.1128/aac.00106-13

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Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites

Journal article published in 2013 by Jandeli Niemand, Pieter Burger, Bianca K. Verlinden, Janette Reader, Annie M. Joubert, Annette Kaiser, Abraham I. Louw, Kiaran Kirk, Otto Phanstiel, Lyn-Marie Birkholtz ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum , with 50% inhibitory concentrations (IC 50 s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.