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Public Library of Science, PLoS Neglected Tropical Diseases, 1(3), p. e354, 2009

DOI: 10.1371/journal.pntd.0000354

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The Effect of Insecticide Synergists on the Response of Scabies Mites to Pyrethroid Acaricides

Journal article published in 2009 by Cielo Pasay, Larry Arlian, Marjorie Morgan, Robin Gunning, Louise Rossiter, Deborah Holt ORCID, Shelley Walton, Simone Beckham, James McCarthy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Synergists are commonly used in combination with pesticides to suppress metabolism-based resistance and increase the efficacy of the agents. They are also useful as tools for laboratory investigation of specific resistance mechanisms based on their ability to inhibit specific metabolic pathways. To determine the role of metabolic degradation as a mechanism for acaricide resistance in human scabies, PBO (piperonyl butoxide), DEF (S,S,S-tributyl phosphorotrithioate) and DEM (diethyl maleate) were used with permethrin as synergists in a bioassay of mite killing. A statistically significant difference in survival time of permethrin-resistant Sarcoptes scabiei variety canis was noted when any of the three synergists were used in combination with permethrin compared to survival time of mites exposed to permethrin alone (p