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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 3(35), p. 363-366, 2015

DOI: 10.1038/jcbfm.2014.235

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Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells

Journal article published in 2015 by Bhimashankar Mitkari, Erja Kerkelä ORCID, Johanna Nystedt, Matti Korhonen, Jukka Jolkkonen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.Journal of Cerebral Blood Flow & Metabolism advance online publication, 7 January 2015; doi:10.1038/jcbfm.2014.235.