Amphiphilic porphyrin derivatives adsorbed onto silica nanoparticles via noncovalent interactions have been prepared and characterized. The organic-inorganic hybrids have been obtained by simply stirring a nanoparticle suspension into an aqueous solvent mixture of porphyrin aggregates. The systems obtained show good stability in aqueous solvents, at different pH, and also in toluene. Analogous protocol has been applied to the macrocycles in monomeric form, obtaining the corresponding nanoparticle-porphyrin adducts. These systems are of interest for the development of sensors and medicinal application.