Nature Research, Nature Neuroscience, 3(8), p. 257-258, 2005
DOI: 10.1038/nn0305-257
Full text: Unavailable
How activity-dependent synaptic plasticity shapes the development of inhibitory synapses has remained unclear. In this issue, Gillespie et al. show that in the developing rat auditory system, inhibitory synapses transiently co-release glutamate. The consequent activation of postsynaptic NMDA receptors may be critical for the plasticity mechanisms that determine tonotopic sharpening.