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National Academy of Sciences, Proceedings of the National Academy of Sciences, 18(99), p. 11778-11783, 2002

DOI: 10.1073/pnas.182314699

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A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

Journal article published in 2002 by Indrajit Nanda, Mariko Kondo, Ute Hornung, Shuichi Asakawa, Christoph Winkler, Atsushi Shimizu, Zhihong Shan, Thomas Haaf, Nobuyoshi Shimizu, Akihiro Shima, Michael Schmid, Manfred Schartl ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The genes that determine the development of the male or female sex are known in Caenorhabditis elegans , Drosophila , and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1Y . This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1Y a candidate for the medaka male sex-determining gene.