Published in
Royal Society of Chemistry, Chemical Science, 10(2), p. 1984
DOI: 10.1039/c1sc00108f
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Sensing coiled-coil proteins through conformational modulation of energy transfer processes - Selective detection of the oncogenic transcription factor c-Jun
Journal article published in 2011 by
Elena Pazos,
Adri An,
Jim Enez-Balsa,
Adrián Jiménez-Balsa 
,
L. Mascare~,
José L. Mascareñas ,
V. Azquez,
M. Eugenio Vázquez,
M. Eugenio Vázquez
,
L. Mascare~,
José L. Mascareñas ,
V. Azquez,
M. Eugenio Vázquez,
M. Eugenio Vázquez
This paper is made freely available by the publisher.
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Abstract
Designed terbium-chelating peptides were used to monitor the formation of leucine zipper associations. The sensing strategy is based on the modulation of the antenna effect from a Trp residue donor and the luminescence increase arising from the folding that takes place upon the formation of the coiled-coil structure. An application in the specific sensing of the oncogenic c-Jun transcription factor is demonstrated.