Elsevier, Bioorganic and Medicinal Chemistry Letters, 8(11), p. 1085-1088
DOI: 10.1016/s0960-894x(01)00140-8
Full text: Unavailable
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.