Published in

Elsevier, Bioorganic and Medicinal Chemistry Letters, 8(11), p. 1085-1088

DOI: 10.1016/s0960-894x(01)00140-8

Links

Tools

Export citation

Search in Google Scholar

Dimeric l-Dopa Derivatives as Potential Prodrugs

Journal article published in 2001 by Antonio Di Stefano, Barbara Mosciatti, Gian Mario Cingolani, Gianfabio Giorgioni, Massimo Ricciutelli ORCID, Ivana Cacciatore, Piera Sozio, Francesco Claudi
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.