We perform multi-plane ray-tracing using the GLAMER gravitational lensing code within high-resolution light-cones extracted from the CoDECS simulations: a suite of cosmological runs featuring a coupling between Dark Energy and Cold Dark Matter. We show that the presence of the coupling is evident not only in the redshift evolution of the normalisation of the convergence power spectrum, but also in differences in non-linear structure formation with respect to {Λ}CDM. Using a tomographic approach under the assumption of a {Λ}CDM cosmology, we demonstrate that weak lensing measurements would result in a {σ}8 value that changes with the source redshift if the true underlying cosmology is a coupled Dark Energy one. This provides a generic null test for these types of models. We also find that different models of coupled Dark Energy can show either an enhanced or a suppressed correlation between convergence maps with differing source redshifts as compared to {Λ}CDM. This would provide a direct way to discriminate between different possible realisations of the coupled Dark Energy scenario. Finally, we discuss the impact of the coupling on several lensing observables for different source redshifts and angular scales with realistic source redshift distributions for current ground-based and future space-based lensing surveys. ; Comment: 17 pag. and 14 fig. replaced to match the accepted version (increased the number of light-cone realisations)