Published in

Elsevier, Bioorganic and Medicinal Chemistry, 7(18), p. 2515-2523, 2010

DOI: 10.1016/j.bmc.2010.02.044

Links

Tools

Export citation

Search in Google Scholar

Enhancement of antiproliferative activity by molecular simplification of catalpol

Journal article published in 2010 by Celina García ORCID, Leticia G. León, Carlos R. Pungitore, Carla Ríos-Luci, Antonio H. Daranas ORCID, Juan C. Montero ORCID, Atanasio Pandiella, Carlos E. Tonn, Víctor S. Martín, José M. Padrón
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed alpha-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86muM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G(1) phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.