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Wiley-VCH Verlag, ChemInform, 16(32), p. no-no, 2001
Elsevier, Tetrahedron Letters, 2(42), p. 311-313
DOI: 10.1016/s0040-4039(00)01772-x
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Studies toward the total synthesis of the variolins: rapid entry to the core structure
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Abstract
The pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine core structure of the variolins has been synthesized in three steps from commercially available materials. The key reaction involves the deoxygenation and concomitant cyclization of a triarylmethanol using the combination of triethylsilane and trifluoroacetic acid. Introduction of amine functionality as required for the natural products has been achieved in two steps. ; http://www.elsevier.com/wps/find/journaldescription.cws_home/233/description#description ; Regan J. Anderson and Jonathan C. Morris