Stress-induced cardiomyopathy is characterized by reversible systolic dysfunction of the ventricles, usually involv- ing the apical segments. It occurs more commonly in women and is frequently precipitated by emotional or phy- sical stressors. Ever since the first report of typical stress-induced cardiomyopathy-usually known as Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome-was issued, variant forms of stress-induced cardiomyopathy have been reported. We describe a patient who presented with typical ischemic chest pain, but who was found to have an atypical form of stress-induced cardiomyopathy: midventricular ballooning syndrome involving both the left and right ventricles. Transthoracic echocardiography and computed tomography were used in this patient. (Korean Circ J 2008;38:677-680)