Dissemin is shutting down on January 1st, 2025

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Oxford University Press, Clinical Kidney Journal, 3(1), p. 151-153, 2008

DOI: 10.1093/ndtplus/sfn016

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Spinal cord compression from a brown tumour despite maximal medical therapy with cinacalcet and sevelamer

Journal article published in 2008 by Chris Wiebe ORCID, Julie Ho, Barry Cohen, Clara Bohm ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background Secondary hyperparathyroidism is a common complication of end-stage renal disease (ESRD), which occurs as a result of hyperphosphataemia, hypovitaminosis D and hypocal- caemia. Chronic hyperparathyroidism can result in osteitis fibrosis cystica, also known as brown tumours. Spinal cord compression from a brown tumour is a rare emergency and of the eight reported cases in the literature, this represents the first case while undergoing treatment with sevelamer and cinacalcet. Although cinacalcet may have a role in the metabolic control of hyperparathyroidism, caution needs to be taken in delay or avoidance of parathyroidectomy in severe cases, as it may cause delays in necessary therapy.