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Baishideng Publishing Group, World Journal of Radiology, 6(6), p. 223, 2014

DOI: 10.4329/wjr.v6.i6.223

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White matter abnormalities: Insights into the pathophysiology of major affective disorders

Journal article published in 2014 by Xenia Gonda, Zoltan Rihmer, Paolo Girardi, Gianluca Serafini ORCID, Mario Amore
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract The presence of white matter hyperintensities (WMHs) has been commonly associated with poor outcome in subjects with major affective disorders. Unfortunately, WMHs may be frequently confounded by the use of psychoactive medications and duration of illness. Although findings from the current literature are quite conflicting, we proposed that subjects with WMHs may be at higher suicidal risk when compared to other subgroups without. Based on the Fazekas modified scale, the severity of WMHs may serve as a trait marker of disease. Interestingly, the presence of WMHs may represent a neurobiological marker between the underlying vulnerability and clinical presentation of major affective disorders.