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Springer Nature [academic journals on nature.com], Genes and Immunity, 1(14), p. 1-6, 2012

DOI: 10.1038/gene.2012.54

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Dual-specificity phosphatases 2: Surprising positive effect at the molecular level and a potential biomarker of diseases

Journal article published in 2012 by W. Wei, Y. Jiao, A. Postlethwaite, J. M. Stuart ORCID, Y. Wang, D. Sun, W. Gu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.Genes and Immunity advance online publication, 29 November 2012; doi:10.1038/gene.2012.54.