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Elsevier, Bioorganic and Medicinal Chemistry, 10(21), p. 2756-2763

DOI: 10.1016/j.bmc.2013.03.021

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Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion

Journal article published in 2013 by Barbara Richichi, Giuseppina Comito, Linda Cerofolini ORCID, Gabriele Gabrielli, Alberto Marra, Lisa Moni, Alice Pace, Lucia Pasquato, Paola Chiarugi, Alessandro Dondoni, Lucio Toma, Cristina Nativi
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A hydrolytically stable mimetic of the tumour antigen GM3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination. © 2013 Elsevier Ltd.All rights reserved.