We present the results obtained with the ISO Long Wavelength Spectrometer on a sample of Pre-MS sources, where several molecular lines of CO, Hensuremath 2ensuremath<?subensuremath>O and OH have been detected. The analysis of the CO lines indicates that gas temperatures as low as 200 K are consistent with the data. This would be in agreement with the relatively low abundance of water in the gas phase measured in most of the objects.