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Cell Press, Cell Metabolism, 5(20), p. 703-705, 2014

DOI: 10.1016/j.cmet.2014.10.017

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C16:0-Ceramide Signals Insulin Resistance

Journal article published in 2014 by Timothy Hla ORCID, Richard Kolesnick
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance.