To investigate the development of xerostomia more than 5 years after radiotherapy for head and neck cancer, a prospective longitudinal study was done. A xerostomia questionnaire was answered by 42 patients 41 and 90 months after radiotherapy: xerostomia at rest did not change significantly over time whereas the difficulties with speaking improved and the difficulties with eating worsened. Subjective xerostomia does not reach a steady state even more than 5 years after radiotherapy. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 98 (2011) 48-50