Wiley, Angewandte Chemie International Edition, 44(47), p. 8460-8463, 2008
Wiley, Angewandte Chemie, 44(120), p. 8588-8591, 2008
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(Chemical Equation Presented) Surprisingly cis-tematic! The cobalt(II) complex of a D2-symmetric chiral porphyrin is an effective catalyst for asymmetric cyclopropanation with α-nitrodiazoacetates (see scheme). The catalytic system is general and suitable for electron-sufficient, -neutral, and -deficient alkenes, forming the corresponding cyclopropane nitroesters in high yields. In addition to high diastereo- and enantioselectivity, the catalytic process exhibits atypical Z selectivity.