This study is focused on early fall season in southern Siberia (50–60 N) and is purposed as a contribution to the discussion on the climatic relevance of October Eurasian snow cover. Analysis is based on the daily snow depth data from 43 stations from years 1980–2012, available in the database of All-Russian Research Institute of Hydrometeorological Information—World Data Centre. The snow cover season in southern Siberia starts in early autumn and the number of days with snowfall varies from less than 5 days in the southernmost zone along the parallel 50 N to more than 25 days in the northeastern part of the analyzed area. October snowfall in southern Siberia is associated with occurrence of negative anomalies of sea level pressure (SLP), usually spreading right over the place of recorded intense snowfall or extending eastward from it. Negative anomalies of air temperature at the 850 hPa geopotential level (T850) occurring with increased cyclonic activity are also observed. Negative T850 anomalies are located west or northwest of the SLP depressions. Counterclockwise circulation around low-pressure systems transports cold Arctic air from the north or even colder Siberian polar air from the east, to the west, and northwest parts of cyclones, and induces negative anomalies of temperature. The pattern of T850 anomalies during heavy snowfalls in the eastern part of the southern Siberia is shifted counterclockwise in regard to SLP anomalies: the strongest negative T850 anomalies are located west or northwest of the SLP depressions.