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Elsevier, Current Opinion in Structural Biology, 6(17), p. 726-735

DOI: 10.1016/j.sbi.2007.08.018

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Taking it Step by Step: Mechanistic insights from structural studies of Ubiquitin/Ubiquitin-like protein modification pathways

Journal article published in 2007 by Allan D. Capili, Christopher D. Lima ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.