Synthesis of P-triazinylphosphonium salts - hybrid molecules with potential antimicrobial activity
Journal article published in 2011 by
Beata Kolesińska 
,
Kamiński Zj,
Rafał Motylski,
Zbigniew J. Kamiński ,
Marek Kwinkowski,
Wiesław Kaca
,
Kamiński Zj,
Rafał Motylski,
Zbigniew J. Kamiński ,
Marek Kwinkowski,
Wiesław Kaca
Abstract
The new hybrid drugs combining in a single molecule triazine ring attached to phosphonium salt were prepared and their bactericidal activity against Gram-positive bacteria Staphylococcus aureus ATCC43300 (MRSA - methycyline resistant Staphylococcus aureus strain) two Gram-negative bacteria Escherichia coli CCUG31997 serotype O153 (EPEC - enteropathogenic Escherichia coli strain), Proteus mirabilis 1784 (MDR - multidrug resistant clinical strain) were determined using microdilution method.