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Impact Journals, Oncotarget, 6(7), p. 6835-6846, 2016

DOI: 10.18632/oncotarget.6899

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Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer

Journal article published in 2016 by Felix Royo, Patricia Zuñiga-Garcia ORCID, Verónica Torrano, Ana Loizaga, Pilar Sanchez-Mosquera, Aitziber Ugalde-Olano, Esperanza González ORCID, Laura Palomo, Sutherland Jd, Ana R. Cortazar, Sonia Fernández-Ruiz, Isabel Lacasa-Viscasillas, Maria Berdasco, James D. Sutherland, Rosa Barrio and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In addition, the characterization of EV in biofluids is an attractive source of non-invasive diagnostic, prognostic and predictive biomarkers. Here we show that urinary EV (uEV) from prostate cancer (PCa) patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH). Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients. Tissue and cell line analysis strongly suggested that the status of CDH3 in uEVs is a distal reflection of changes in the expression of this cadherin in the prostate tumor. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. Our results reveal that uEVs could represent a non-invasive tool to inform about the molecular alterations in PCa.