Elsevier, Journal of Molecular and Cellular Cardiology, (73), p. 70-79
DOI: 10.1016/j.yjmcc.2014.02.006
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The only known function of Nox family NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article. This article is part of a Special Issue entitled Redox Signalling in Heart.