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Published in

BMJ Publishing Group, Journal of Neurology, Neurosurgery and Psychiatry, 4(71), p. 538-541, 2001

DOI: 10.1136/jnnp.71.4.538

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Relapsing intracranial Rosai-Dorfman disease

Journal article published in 2001 by A. Petzold ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Two patients presenting with recurrent visual impairment due to relapsing intracranial Rosai-Dorfman disease are described. In both patients a preoperative diagnosis of meningioma was made. Histological examination disclosed the characteristic picture of S100 and CD68 positive histiocytosis with prominent lymphophagocytosis. In both patients complete tumour removal by surgery was impossible with residual tissue being the origin of relapsing disease. Low dose radiation led to partial recovery of vision and resolution of the intracranial mass. Review of the literature on intracranial Rosai-Dorfman disease leads to the suggestion that postoperative radiotherapy may be advisable in all cases.